Four enzymes are necessary for effectively removing the all forms or surgical bioburden when cleaning surgical instruments, utensils, and scopes. Surgical instrument cleaning enzymes are proteins that act as catalysts to speed up chemical reactions that would otherwise occur at a much slower rate. Surgical instrument cleaning Enzymes fit their different forms of target substrates (surgical bioburden) like a lock fits a key. The surgical instrument cleaning enzymes active site is open only to specific target substances with a matching chemical shape. If the substrate doesn't fit, the surgical instrument cleaning enzymes cannot enter and no reaction occurs. This makes the action of surgical instrument cleaning enzymes highly specific for their substrates. For this reason four enzymes are needed for effectively cleaning surgical instruments and removing the bioburden. Protease surgical instrument cleaning enzymes breakdown proteins including blood. Amylase surgical instrument cleaning enzymes breakdown starch and catalyze the hydrolysis of starch. Lipase surgical instrument cleaning enzymes breakdown fats and high level lipids. Carbohydrase surgical instrument cleaning enzymes breakdown high level starches into lower level starch molecules for rapid degradation and removal. Enzyme Detergents that do not offer these 4 enzymes cannot remove all forms of proteinaceous bioburden and will be as effective for cleaning surgical instruments.
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Enzymes fit their target substrates like a lock fits a key.The active site of the  enzyme is open only to specific target substances with a matching chemical. If the substrate doesn't  fit no reaction occurs. This makes the action of surgical instrument cleaning enzymes highly specific for their substrates. For this reason specific enzymes are needed for cleaning surgical instruments, removing the bioburden. Protease Enzymes breakdown proteins including blood, Amylase Enzymes breakdown starches and catalyze the hydrolysis of starch, Lipase Surgical Instrument Cleaning Enzymes breakdown fats and high level lipids, and Carbohydrase Enzymes breakdown high level starches. Enzyme Detergents that do not offer these 4 enzymes cannot remove all forms of proteinaceous bioburden and will be as effective for cleaning surgical instruments. Enzyme Surgical instrument cleaning detergents can clean for long time periods and can be reused. Like other types of catalysts, an enzyme can complete its chemical reaction without being used up or destroyed, leaving the enzyme protein available for yet another reaction. This means that one enzyme protein molecule can act on many substrate molecules. Eventually, all the substrate is gone and the enzyme stops working. The level of bioburden contained within the enzyme solution being used for cleaning surgical instruments can become a burden for effective cleaning. The initial decontamination of surgical instruments should begin immediately after the completion of any surgical procedure. The cleaning surgical instruments should be performed as soon as possible after use. The application of a neutral pH four enzyme (enzymatic) detergent will prove to be effective in speeding the cleaning of surgical instruments and will lower the overall handling costs for reprocessing surgical instruments. Used Surgical instruments are always considered to be contaminated by unidentified microorganisms and the presence of pathogens is unknown. The critical cleaning of surgical instruments is necessary for the protection of the patients and healthcare professionals and to prevent the transmission of pathogens. Manual hand washing surgical instruments, ultrasonic surgical instrument cleaners, automated instrument washers, and washer disinfectors have all proven to be effective if they perform the recognized Proper Sequence of Surgical Instrument Cleaning Treatments which include: cold water pre-wash with a 4 enzyme cleaner, elevated temperature wash with a neutral pH detergent, final purified water rinses, and hot air drying with instrument lubrication. Saline causes deterioration of surgical instruments and should never be used when cleaning surgical instruments. The enzymes used in surgical instrument cleaning enzyme detergents act on materials that make up a variety of stains and soils so that these  materials can be washed away more easily. These enzymes are named after  the materials they can act upon, for example, protease break down  protein based stains, lipolases break down lipid fat based stains and  amylases break down starches and other carbohydrate based stains. Since one enzyme molecule can act on many substrate molecules, a small amount of enzyme added to a laundry  detergent can provide a big cleaning benefit to the consumer. When surgical instrument are not soaked to maintain hydration prior to cleaning, it increases the probability that particles of tissue, bone, and blood will adhered to surgical instruments and  resist the cleaning process. This will cause corrosion to surgical instruments and will degrade the passive Layer of protection of the surgical stainless steel. A 4 enzyme detergent surgical instrument cleaner soak will facilitate the decontamination and cleaning of these surgical instruments and hard-to-clean surgical instruments. Are Surgical instrument cleaning enzyme detergents safe? Enzymes are proteins, therefore, they are completely biodegradable. They are non-toxic to plants and animals in the environment. They are harmless if accidentally ingested by a child. However, like many other proteins, enzymes can cause respiratory allergy in some people if they  are breathed in at very high concentrations, frequently, and for long  periods of time. This doesn't pose a safety issue for consumers who use  laundry detergents. However, this can represent a health issue for people that work in enzyme making facilities and in detergent production facilities, especially if enzymes are not handled properly. How are respiratory allergies affected by enzyme surgical instrument cleaning detergents? Frequent inhalation of surgical instrument cleaning enzymes at high concentrations over a long period of time can lead to respiratory allergy among some people. This can occur among people that have to work with surgical instrument cleaning enzymes and when the enzymes are not handled properly. Minimize creating surgical instrument cleaning enzyme aerosols, Use surgical instrument cleaning enzymes in a liquid or foam state to avoid creating aerosols, When surgical instrument cleaning enzymes are used with ultrasonic cleaning always keep the tank lid closed. Provide ventilation to avoid excessive exposure to potential surgical instrument cleaning enzyme aerosols, use surgical instrument cleaning enzymes in a foam state when soaking instruments prior to cleaning, always wear the recommended protective apparel when using surgical instrument cleaning enzymes. Enzyme surgical instrument cleaning detergents are recommended for challenging and rapid cleaning tasks due to their ability to break soil down to a form that can be removed from surfaces that are difficult to clean, and most importantly, deliver the surfactant detergents needed to clean that bioburden from the surface. Surgical instrument cleaning enzyme detergents are recommended for cleaning surgical instruments that are heavily contaminated with encrustation, the emulsification of lipid bioburden, and encased surgical compounds, i.e. bone glues.
John Temple Director of Product Development for Surgical Instrument Cleaners
The Lubricant Detergent Enzyme Surgical Instrument Cleaners replace multiple products, including: enzyme surgical instruments cleaners, surgical instrument cleaning detergents, surgical instrument cleaners, surgical instrument cleaning detergents, surgical instrument lubricants, eye surgical instrument detergents, surgical instrument detergents, surgical instrument washer detergents, and enzymatic cleaners for surgical instruments.

Surgical Instrument Cleaning Detergents
Surgical Instrument Cleaning Detergents